6. Micelles solubilize molecules of poorly soluble nonpolar pharmaceuticals in/at: 3). Core of the micelle b)Shell of the micelle c) Continuous aqueous phase d) Surfactant 7. At and above CMC the surface tension of liquid: a) Increase b) Decrease c) Remain constant d) depend on nature of surfactant 8. Which of the following is/are the good conductor of electricity? A) Ionic surfactants b) Non-ionic surfactants c) Micelles d) Association colloids 9. The aggregation of molecules into micelles will lead to increased: a) Transmission of light b) Scattering of light c) Absorption of light d) All of these 10. Shelf-life is the time required for a drug product to degrade by: a) 20% b) 50% 10% d) 100% 11. The prerequisite for the acceptance and approval of any pharmaceutical product is: a) Solubility b) Stability c) Shelf-life d) All of these 12. Stability studies are required to be conducted in a planned way following the guidelines issued by: a) FDA b) ICH c) WHO d) B &C 13. The storage conditions in accelerated stability studies are: a) 50^circ Cpm 2 and 60pm 10RH b) 50^circ Cpm 2 and 80pm 5 RH 40^circ Cpm 2 and 75pm 5RH d) 60^circ Cpm 2 and 80pm 10RH

6. The correct answer is a) Core of the micelle. Micelles are spherical structures formed by surfactant molecules in a solution. The core of the micelle is the region where the nonpolar pharmaceutical molecules are solubilized, while the shell is the region where the polar heads of the surfactant molecules are located.<br /><br />7. The correct answer is b) Decrease. At and above the critical micelle concentration (CMC), the surface tension of the liquid decreases. This is because the surfactant molecules reduce the surface tension by minimizing the contact between the liquid and the air.<br /><br />8. The correct answer is a) Ionic surfactants. Ionic surfactants are good conductors of electricity because they dissociate into charged ions in the solution. These ions can carry electric current, making ionic surfactants good conductors.<br /><br />9. The correct answer is b) Scattering of light. The aggregation of molecules into micelles leads to an increase in the scattering of light. This is because the micelles have a larger size compared to individual molecules, which causes the light to scatter more.<br /><br />10. The correct answer is b) 50%. Shelf-life is defined as the time required for a drug product to degrade by 50%. It represents the period during which the product remains stable and maintains its intended properties.<br /><br />11. The correct answer is d) All of these. The acceptance and approval of any pharmaceutical product require solubility, stability, and shelf-life. Solubility ensures that the drug is able to dissolve in the body fluids, stability ensures that the drug remains unchanged during storage and use, and shelf-life ensures that the drug remains stable for a certain period of time.<br /><br />12. The correct answer is d) B & C. Stability studies are required to be conducted in a planned way following the guidelines issued by the International Conference on Harmonization (ICH) and the World Health Organization (WHO). These organizations provide guidelines for the conduct of stability studies to ensure the safety and efficacy of pharmaceutical products.<br /><br />13. The correct answer is c) $40^{\circ }C\pm 2$ and $75\pm 5RH$. In accelerated stability studies, the storage conditions are set to be more extreme than those used in normal storage conditions. The temperature and relative humidity (RH) are increased to accelerate the degradation of the drug product. The specific conditions mentioned in option c) are commonly used in accelerated stability studies.