has of planna memberane integrity and swelling of the cell body followed by death). ancuploidy due to non -dinjunction in sex a direct genotoxic carcitogen. so FDA classification of drug risk (as a possible teratogen) during promancy Thalidomide is in the X category. Which of the following base-pair mutations is property characterized as a Chasvension mutation? a) Tarrow C b) Aarrow G G- A. (1) Tarrow U Aarrow C (Lon) 12. What are the 2 important factors for the CYPs to canalyse the oxidation reactions? ANADPILIH + NADPH-eylochrome P450 b) NADH,II +Phospholipids NADPH_(3)H+O_(2) (4) O_(2).Phospbolipid c) CO+NADH,H (1.07) 13. Whish one of the following CYP is not expressed in human liver? a) CYP2C9 b) CYP3A4 c) CYP2D6 d) CYPIAI c) CYP2B6 14. Adaptation of toxicity may result from biological changes causing the below processes with the exception of one Which of the following statement ks EALSE 7 a)Diminisbed delivery of the toxicant to thetarget. b) Decrease DNA repair capacity. c) Issreased capacity of the organism to repair itself. d) Strengthened mechnisms to compensate the toxicant caused dysfunction. e) Decreased size or susceptibility of the target. (109) 15. Which of the following is not among the primary metabolic disorders jespardizing cell survival? a)ATP depletion b) Sustained rise in intracellular Ca2+ c) Overproduction of ROS, d) Overproduction of RMS e)Increase cytosolic Glutathione level (LO9) 16. Which of the following agent that does not impair ATP synthesis? a)Rotenone b) Paracetamol c)Paraquat d)DDT e)Cyanide